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. 2018 Jul 25;38(30):6787–6801. doi: 10.1523/JNEUROSCI.2352-17.2018

Figure 1.

Figure 1.

Proposed pathway for wnt3a activation of Frz1 and its downstream targets. wnt3a binds to Frizzled-1, increases PIWIL1a, inhibits the activation of GSK3β, and activates β-catenin, which translocates into the nucleus to increase the transcription of FOXM1, a survival protein that inhibits apoptosis.