Figure 14.

LRP6 expression and activation after MCAO in rats. Right hemisphere representative Western blots of the rat brain for LRP6, pLRP6, and actin. Overall LRP6 expression was not significant between groups. However, phosphorylation of LRP significantly increased in the HD treatment (1.2 μg/kg) treated groups, which was reversed in the Frz1-siRNA at 24HR after MCAO. Each column represents the mean ± SD (n = 6/group). *p < 0.05 versus Sham. ^#p < 0.05 versus vehicle. ^&p < 0.05 versus wnt3a + Scr siRNA.