Figure 8.

Aspirin reduces intraneuronal Aβ accumulation. 5XFAD mice (6–7 months old, n = 6) were treated orally with aspirin (2 mg/ kg body weight/d) or vehicle (.1% methylcellulose) for 1 month, after which the intraneuronal level of Aβ in the cortex was monitored by double labeling with NeuN and Aβ 6E10 (A), quantification of NeuN+ Aβ+ cells (B), and quantification of NeuN+ cells in the cortex by ImageJ (C). Eighteen images (20× magnification) from six different mice per group were quantified. One-way ANOVA followed by Tukey's multiple-comparisons test was used for statistical analysis; **p < 0.001.