Skip to main content
. 2018 Jul 25;38(30):6628–6639. doi: 10.1523/JNEUROSCI.2152-17.2018

Figure 6.

Figure 6.

Inhibition of Cox-2 suppresses t-LTP in ascending projection neurons. A, Examples of monosynaptic EPSCs evoked by dorsal root stimulation before (black) and after (gray) the administration of the t-LTP pairing protocol in the presence of the selective Cox-2 inhibitor nimesulide. B, Current versus time plot illustrating the limited potentiation of EPSC amplitude that occurs when the t-LTP pairing protocol is administered (black bar) in the presence of nimesulide. C, The Cox-2 inhibitor significantly reduced the magnitude of t-LTP compared with the vehicle control (DMSO: n = 4; nimesulide: n = 6; **p = 0.009; Mann–Whitney test).