Fig. 3.

Immunohistochemical detection of CYP2C9 and CYP2C19 expression in the human amygdala, basal ganglia, and cerebellum. Negative controls incubated with preimmune sera for CYP2C9 and CYP2C19 were performed with the molecular layer of the cerebellum but were representative of other areas. Both P450s were expressed in the amygdala, basal ganglia, and cerebellum. In the amygdala, expression was predominantly localized in the soma of neurons, whereas both somatic and axonal expression of both CYP2C9 and CYP2C19 was observed in the basal ganglia. Expression of both CYP2C9 and CYP2C19 was localized to the pyramidal cells and the granular cell layer of the cerebellar cortex. Bar, 50 μm.