TABLE 2.

Correlation analysis (r) of the relationship between the rates of TMP primary metabolite formation with the sample-to-sample variation in cytochrome P450 activities in human liver microsomes

TMP Concentration	1-NO-TMP	3-NO-TMP	3'-Desmethyl-TMP	4′-Desmethyl-TMP	Cα-OH-TMP	Cα-NAC-TMP
CYP1A2
5 μM	0.444	0.710**	0.578*	0.437	0.247	0.232
50 μM	0.434	0.785**	0.555*	0.409	0.235	0.221
CYP2A6
5 μM	0.633**	0.435	0.554*	0.566*	0.506*	0.493
50 μM	0.587**	0.391	0.512*	0.558*	0.488	0.488
CYP2B6
5 μM	0.499*	0.145	0.055	0.352	0.521*	0.510*
50 μM	0.404	0.077	0.000	0.316	0.459	0.457
CYP2C8
5 μM	0.734**	0.884**	0.750**	0.930**	0.302	0.292
50 μM	0.612*	0.807**	0.694**	0.867**	0.303	0.286
CYP2C9
5 μM	0.742**	0.629**	0.873**	0.759**	0.502*	0.499*
50 μM	0.763**	0.616*	0.888**	0.809**	0.537*	0.528*
CYP2C19
5 μM	0.429	0.152	0.145	0.239	0.500*	0.502*
50 μM	0.379	0.152	0.122	0.255	0.424	0.428
CYP2D6
5 μM	0.110	0.167	0.436	0.190	0.032	0.045
50 μM	0.167	0.190	0.481	0.251	0.063	0.055
CYP2E1
5 μM	0.110	0.032	0.226	0.000	0.190	0.192
50 μM	0.197	0.000	0.167	0.000	0.237	0.251
CYP2J2
5 μM	0.510*	0.089	0.438	0.390	0.548*	0.571*
50 μM	0.540*	0.095	0.514*	0.518*	0.573*	0.571*
CYP3A4/5
5 μM	0.853**	0.148	0.399	0.509*	0.991**	0.990**
50 μM	0.905**	0.138	0.466	0.632*	0.994**	0.995**
CYP4A11
5 μM	0.389	0.512*	0.458	0.489	0.164	0.179
50 μM	0.423	0.544*	0.511*	0.511*	0.217	0.219

^*P < 0.05; **P < 0.01.