TABLE 2.

Brain pharmacokinetic values of C-DIM compoundsData representing the mean of three animals per time point per C-DIM compound were used for the construction of brain tissue concentration versus time curves (Fig. 4).

Noncompartmental modeling was used for the calculation of pharmacokinetic parameters based on the composite data.

C-DIM (brain)	AUC0->720 min	Cmax	t1/2λ	Tmax	CL(area)/kg	Kelλ	Brain AUC: Plasma AUC
	(ng/ml) × min	ng/ml	min	min	ml/min×kg	(μg/ml) × min2
C-DIM5 I.V.	23,192	216	47	30	261	0.0146	6.0
C-DIM5 Oral	88,325	378	44	120	647	0.0157	6.0
C-DIM7 I.V.	39,397	313	147	10	103	0.0047	4.1
C-DIM7 Oral	171,596	887	112	120	338	0.0062	5.8
C-DIM8 I.V.	16,165	151	248	10	109	0.0028	1.8
C-DIM8 Oral	16,322	31.2	187	360	1,941	0.0037	3.2
C-DIM12 I.V.	68,042	272	117	10	36.5	0.0059	2.4
C-DIM12 Oral	465,845	1,173	95	240	86.3	0.0073	4.1

AUC, area under the curve; C-DIM, para-phenyl subsitiuted diindolylmethane; CL, clearance limit; K_el, elimination rate.