TABLE 5.

Dopamine and DOPAC levels in the striatum

A separate set of mice from the same MPTPp study used in stereological and TH intensity assessment (Table 4) were also analyzed for striatal levels of dopamine and its primary metabolite DOPAC with use of HPLC. Data are expressed as mean ± S.E.M. (n = 5 animals per group).

Treatment	SAL	MPTPp 7 Days	MPTPp 14 Days	MPTPp 14 Days Plus C-DIM5	MPTPp 14 Days Plus C-DIM8	MPTPp 14 Days Plus C-DIM12
Dopamine, ng/mg	49.0 ± 6.7	20.3 ± 2.3*	7.0 ± 3.9*	6.4 ± 1.4*	8.4 ± 2.3*	11.9 ± 3.9*
DOPAC, ng/mg	3.9 ± .81	2.5 ± .32	0.9 ± .14*	0.8 ± .13*	1.1 ± .14*	1.4 ± .35*

DOPAC, 3,4-dihydroxyphenylacetic acid; HPLC, high performance liquid chromatography; MPTPp, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyradine with probenecid; SAL, control; TH, tyrosine hydroxylase.

^*P < 0.05 compared with saline control.