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. 2014 Mar;348(3):383–392. doi: 10.1124/jpet.113.208108

Fig. 5.

Fig. 5.

Effects of opioid receptor antagonists on antinociception by subcutaneous administration of MGM-15 (A) and MGM-16 (B). The antinociceptive effects of MGM-15 and MGM-16 were determined in mice by the tail-flick test after subcutaneous administration of the following antagonists: β-FNA (40 mg/kg), naloxonazine (NLZ; 35 mg/kg), NTI (3 mg/kg), and norBNI (20 mg/kg). Measurements were performed 15 minutes after subcutaneous administration of MGM-15 (0.5 mg/kg) or MGM-16 (0.1 mg/kg) in the tail-flick test. Each value represents mean ± S.E.M. of eight or nine mice. ###P < 0.001 vs. vehicle-treated mice by Student’s t test. **P < 0.01; ***P < 0.001 vs. MGM-15 or MGM-16 by Bonferroni correction.