Fig. 6.

Effects of MGM-16 on mechanical allodynia in partial sciatic nerve–ligated mice. MGM-16 was administered subcutaneously (A) and orally (B), and the paw withdrawal thresholds on the ipsilateral side were determined repeatedly. Gabapentin (Gab; 100 mg/kg) was administered orally as a positive control. Several doses of MGM-16 and 100 mg/kg gabapentin are presented at 0.5 and 1 hour after administration, respectively. Each value represents mean ± S.E.M. of six or seven mice. **P < 0.01; ***P < 0.001 vs. vehicle by Bonferroni correction.