TABLE 6.

ED₅₀ values of antinociceptive effects and IGIT produced by oral administration of morphine, 7-hydroxymitragynine (7-OHMG), MGM-15, and MGM-16 in mice

ED₅₀ represents the median effective dose (mg/kg) (95% confidence limits).

Test	ED50 of:
	Morphine	7-OHMG	MGM-15	MGM-16
	mg/kg
Tail-flick	63.0 (37.2–106.8)	4.43 (1.57–6.93)	1.26 (0.84–1.88)	0.263 (0.165–0.420)
IGIT	11.7 (5.6–24.6)	7.50 (3.95–14.2)	2.20 (0.18–0.70)	0.451 (0.230–0.882)