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. 2018 Jul 31;13(7):e0198004. doi: 10.1371/journal.pone.0198004

Table 1. Moderating effect of number of prescribed ATC codes on health care costs during first quarter of PIM use.

NEG EG Difference
Costs in € Effect of ATC (SE) Effect of ATC (SE) Moderating effect of ATC (SE) p-value R2
Medication 70.39 (0.36) 58.87 (0.46) -11.52 (0.58) 0.000 0.164
Outpatient physician services 33.28 (0.17) 28.76 (0.21) -4.47 (0.27) 0.000 0.107
Hospital treatment 79.54 (1.54) 240.04 (2.02) 160.50 (2.54) 0.000 0.007
Rehabilitation 5.40 (0.18) 15.03 (0.25) 9.63 (0.31) 0.000 0.007
Medical supplies 2.54 (0.04) 2.12 (0.05) -0.42 (0.07) 0.000 0.014
Total costs 195.99 (1.66) 333.20 (2.18) 137.20 (2.74) 0.000 0.090

The calculation of moderating effects of the number of prescribed ATC codes in the incident quarter of PIM use is based on fully saturated linear mixture regression models with maximum likelihood estimators with a quadratic term for the number of prescribed ATC codes. Calculation of moderating effect of ATC is based on the interaction effect between the study group (EG vs. balanced NEG) and the number of prescribed ATC codes in the 1st quarter of the post-period. The statistical fit of the single models is shown in the last column in form of the Maddala-R2 which is based on the maximum-likelihood.