Table 3.

Patients with serious adverse events reported

No	Event	Considered related to NECT	Death	Compatible with reactive encephalopathy?
1	Depressed level of consciousness with fever and death	No	Yes	No
2	Coma with seizures and death	Yes	Yes	Yes
3	Coma with seizures and fever	Yes	No	Yes
4	Coma with hypotension, seizures, fever, and death	Yes	Yes	Yes
5	Ataxia and urinary retention	Yes	No	No
6	Psychotic reaction	Yes	No	No
7	High fever and death	No	Yes	No
8	High fever and death	Yes	Yes	Yes
9	Agitation, abnormal behavior, fever, and encephalopathy	Yes	No	Yes
10	Severe anemia and death	No	Yes	No
11	Fever and seizures	Yes	No	Yes
12	Fever, seizures, coma, and death	Yes	Yes	Yes
13	Repeated seizures	Yes	No	Yes
14	Severe dyspnea	Yes	No	No
15	Seizure and encephalopathy	Yes	No	Yes
16	Paralysis	Yes	No	No
17	Seizure, confusion, paralysis	Yes	No	Yes
18	Acute abdomen and death	No	Yes	No
19	Confusion, coma, and death	Yes	Yes	Yes

Abbreviation: NECT, nifurtimox-eflornithine combination therapy.