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. 2018 Jul 26;9(1):1001–1007. doi: 10.1080/21505594.2018.1486140

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Comparative genomics of pLSB54-mcr-1 and pLSB54-NDM-5.

A. Cartoon description of the E. coli LSB54 strain carrying the two plasmids pLSB54-mcr-1 and pLSB54-NDM-5B. Colinear genome analyzes of three mcr-1-harboring plasmids pLSB54-mcr-1, pHNSHP45-2 (KU341381) and p2474-MCR1 (CP021209)C. Genomic comparison of the plasmid pLSB54-NDM-5 with two other NDM-5-expressing plasmids pCREC-591_4 (CP024825) and pNDM_MGR194 (KF220657)Boxed arrows represent the position and transcriptional direction of the ORFs. Regions of > 99% identity are given by green shading. Genes associated with the tra and pil loci are colored light blue, antibiotic resistance genes are colored red, insertion sequences are colored green, and other genes are colored black.