Figure 2.

Efficiency of protection against RSV in juvenile cotton rats born from vaccinated, unprimed or primed mothers. (A) Female cotton rats were separated into three groups. One group of females remained unprimed and unvaccinated (Group A) as a control. Another group was primed by infection with RSV i.n. and then vaccinated with live RSV i.m. two weeks after priming and boosted during pregnancy (Group B). The last group of females remained unprimed, but was vaccinated and boosted (Group C). Litters from mothers in each group were challenged 4 weeks after birth and euthanized on day 4 post-challenge. (B) Quantification of lung and nose viral titers in samples of RSV-challenged, 4-week old juvenile cotton rats. Bars represent the mean ± SE. The inhibitory effect on vaccination in seropositive mothers was evaluated by comparing litters born from mothers in Group B (primed) and Group C (unprimed). N = 13-25 pups per group. ANOVA followed by Student-Newman-Keuls post hoc test. *p < 0.01. Data taken from reference.⁷