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. 2018 Jun 20;14(7):1686–1696. doi: 10.1080/21645515.2018.1480284

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© 2018 The Author(s). Published with license by Taylor & Francis

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 4. — Discrimination between extracellular and intracellular innate immune receptors by CXC chemokine profiles. The extracellular TLRs 2, 4, and 5 showed strong upregulation of CXCL5, CXCL6 and CXCL8, while the endolyososomal TLRs 3, 7, and 8 were characterized by upregulation of CXCL11 and CXCL12. Heat maps of fold change (means of duplicate samples, EDGE test validated) are shown.