Table 1.
Clinical features in 22 cases of ovarian dysgerminoma in pregnancy.
| Study | Age (years) | Parity | Onset (GA, weeks) | Onset symptom | Delivery (GA, week) | Surgical intervention | Side | Tumor Size (cm) | FIGO stage | Non-operative treatment | Fetal outcome | Maternal prognosis |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1.Schneider62 (1947) | 23 | 1 | last puerperium | Abdominal pain | 39 + 2, CS | LSO, at CS | Left | 13× 13× 6 | IA (unstaged) | None | 2,892 g, healthy | NA |
| 2.Watson63 (1956) | 25 | 1 | 3rd trimester | Obstructed labor | Term, CS | Oophorectomy, at CS | Right | 14× 12× 11 | IA (unstaged) | None | healthy | A/W 32 months |
| 3.Misra64 (1958) | 20 | 2 | 23 | Abdominal pain | 25, VD | Oophorectomy, 24 + 3 weeks | Right | 18× 17× 8 | IA (unstaged) | None | Abortion, at 24 + 6 weeks | A/W 3.5 years |
| 4.Pece65 (1964) | 26 | 2 | 1st trimester | None AS by palpation | 40, VD | RSO, 2 months after VD | Right | 26× 23× 19 | IIIC (unstaged) | CT | 3,000 g, hare lip | NA |
| 5.Smith66 (1966) | 18 | 0 | 42 | Obstructed labor | 42, CS | BSO, at CS | Left | 15× 14× 7 | IIIB (unstaged) | RT | 3,544 g | Dead, 10 weeks |
| 6.Karlen67 (1979) | 20 | 0 | 32 | Abdominal pain | 36, CS | TAH + BSO + AE + OE at CS | Left | 28 | IB | NA | 2,730 g, healthy | A/W 3 years |
| 7.Rabinowitz68 (1985) | 22 | 0 | None | None found in CS | 33, CS | RSO, at CS | Right | 5 | IA (unstaged) | None | 2,900 g, dead of Potter's Syndrome | A/W 2 years |
| 8.Rabinowitz68 (1985) | 26 | 2 | None | None found in CS | 39, CS | RSO, at CS | Right | 6 | IA (unstaged) | None | 2,750 g, healthy | A/W 3 years |
| 9.Kulenthran69 (1986) | 17 | 0 | 24 | None AS by palpation | 40 + 5, VD | RSO, 24 + 4 weeks | Right | 5× 8× 6 | IA (unstaged) | None | 2,950 g, healthy | A/W 15 years |
| 10.Kulenthran69 (1986) | 21 | 1 | 20 | None AS by palpation | 34, VD | LSO, 3rd day after VD TAH + RSO + AE + OE, after 5 cycles of CT | Left | 20× 18× 15 | IA | CT × 9 cycles, (4 after second surgery) | 1,900 g | A/W 1 years |
| 11.Buller54 (1992) | 26 | 0 | 23 + 4 | None AS by ultrasound | Term, VD | Oophorectomy, 25 weeks | NA | 16 | IA (unstaged) | None | NA | A/W 2 years |
| 12.Buller54 (1992) | 28 | 0 | 10 | None AS by MRI | 38, VD | Stage surgery, 10 weeks | Right | 13× 9× 7 | IA | None | healthy | A/W 7 months |
| 13.Buller54 (1992) | 21 | 2 | 9 | None AS by palpation | 38, VD | RSO + OE + left ovary biopsy 26 weeks | Right | NA (weighed6,300 g) | IV | CT × 4 cycles (27–37 weeks GA) | 2,320 g, IUGR | A/W 9 months |
| 14.Ueda70 (1996) | 30 | 1 | NA | NA | 15, CS | LSO, 13 weeks TAH + RSO, 15 weeks | Left | NA | IB | RT | None (TAH at 15 weeks) | A/W 10 years |
| 15.Sayedur3 (2002) | 18 | 0 | 24 | Abdominal pain | Term, VD | RSO, 24 weeks | Right | NA | IA (unstaged) | RT | healthy | A/W 5 years |
| 16.Hubalek10 (2007) | 33 | 0 | 22 | None AS by ultrasound | 35 + 3, CS | TAH + BSO + OE + SLA, at CS | Right | 18× 12× 8 | IC | CT × 3 cycles (25–32 weeks GA) | 2,450 g, healthy | A/W 22 months |
| 17.Gauza71 (2010) | 25 | 0 | 31 | Abdominal pain | 39, CS | LSO, at CS OE + peritoneal biopsy + lavage, 45 days after CS | Left | 23× 18× 11 | IA | None | 2,700 g, healthy | NA |
| 18.Gezginc2 (2011) | 32 | 1 | 34 | Abdominal distention | 36, CS | Bilateral ovarian biopsy, at CS | NA | 30 | IV | CT | 1,700 g, IUGR | Dead 10 months |
| 19.Akhtar72 (2011) | 22 | 0 | 32 | Abdominal distention | 32, CS | RSO, at CS | Right | 35× 25 | IA (unstaged) | CT × 6 cycles | healthy | A/W 2 years |
| 20.Montesinos11 (2012) | 24 | 0 | 1st trimester | Abdominal pain | Ectopic pregnancy | RSO + left salpingostomy, 1st trimester | Right | 14 | IA (unstaged) | None | None | A/W 7 years |
| 21.Gupta12 (2016) | 28 | 1 | None | None found in CS | 35 + 3, CS | Bilateral salpingectomy + tumors resection, at CS | Left& Right | 15× 9 (L), 3× 5 (R) | IB (unstaged) | CT × 6 cycles | 2,220 g, healthy | A/W 3 months |
| 22.Our case | 23 | 1 | 7 | None AS by ultrasound | 34 + 6, CS | RSO + retroperitoneal mass resection, at CS | Right | 18× 13× 10 | IIB (unstaged) | CT × 6 cycles | 2,200 g, healthy | A/W 6 months |
AE = appendectomy; AS = abdominal mass; A/W = alive and well; BSO = bilateral salpingo-oophorectomy; CS = cesarean section; CT = chemotherapy; EP = ectopic pregnancy; IUGR = intrauterine growth restriction; GA = gestational age; LSO = left salpingo-oophorectomy; NA = not available; OE = omentectomy; RT = radiation therapy; RSO = right salpingo-oophorectomy; SLA = systematic pelvic and paraaortic lymphadenectomy; TAH = total abdominal hysterectomy; VD = vaginal delivery.
The International Federation of Gynecology and Obstetrics (FIGO) staging system is used for staging.