Table 3.

Chimpanzee adenoviral vectors in cancer research.

Adenovirus	Vector	Features	Anti-tumor effects
AdC7	AdC7-SP/E1A-ΔE3	Replication-selective; Induces cell death through apoptosis via the pro-apoptotic protein BAD mediated mitochondrial pathway	Showed significant anti-tumor effects in some certain cancer cells as well as in tumor-bearing mice
AdC68	AdC68-CTB	Replication-defective; Expresses cetuximab that is an anti-EGFR monoclonal antibody against cancer	Effectively suppressed tumor growth in NCI-H508 or DiFi- inoculated nude mice