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Risk-adapted treatment of chronic lymphocytic leukemia. CIRS = Cumulative Illness Rating Scale; HDMP = high-dose methylprednisolone; ulgHV = unmutated immunoglobulin heavy-chain variable gene; mlgHV = mutated IgHV; FCR = fludarabine, cyclophosphamide, and rituximab; FR = fludarabine and rituximab; PCR = pentostatin, cyclophosphamide, rityximab; BR = bendamustine and rituximab. aNCCN Category 1 designation.
