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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Neuropharmacology. 2018 Jun 28;139:26–40. doi: 10.1016/j.neuropharm.2018.06.037

Figure 3. EGR1, EGR2 and OPRM1 gene expression.

Figure 3

Relative gene expression was assessed via RT-qPCR on genes EGR1, EGR2 and OPRM1 in the VTA, mPFC and NAc. (A) Differential expression of EGR1 was observed between SS and EH, ES and EH, and SH and EH in the mPFC. Higher expression of EGR1 was observed in the SS group relative to ES, SH and EH. (B) Differential EGR2 expression was observed between SS and SH, ES and EH, and SH and EH in the mPFC. In the NAc, SS had higher expression of EGR2 relative to EH and SH. (C) No differences in OPRM1 expression were observed in the VTA, mPFC or NAc *p<0.05 **p<0.01, ***p<0.001, (B) ANOVA n=5–10/group (standard saline = SS, enriched saline = ES, standard heroin = SH enriched heroin = EH)