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. 2018 Jun 14;89(6):413–422. doi: 10.1159/000488347

Fig. 4.

Fig. 4.

Effects of a KDM6A inhibitor (GSK-J1) on responses of normal isolated mouse islets. Isolated mouse islets were first cultured with KDM6A inhibitor (GSK-J1), 0.5 µM, for 3 days, removed from GSK-J1 during a 30-min glucose-free preincubation, and then exposed to different concentrations of glucose for another 30 min in the absence of the inhibitor. a GSK-J1-G SIS-mouse. Islets incubated with GSK-J1 (filled circles) exhibited a leftward shift in glucose-stimulated insulin secretion with increased release of insulin at 10 and 25 mM glucose compared to control islets (open circles). * p < 0.05, ** p < 0.01, vs. control. b Basal cytosolic calcium was initially elevated in islets following exposure to GSK-J1 inhibitor (black line) during 3 days of culture, but showed similar cytosolic calcium responses compared to control islets (grey line) during perifusion with 5 or 10 mM glucose (G) in the absence of GSK-J1.