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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Curr Top Med Chem. 2018;18(8):674–699. doi: 10.2174/1568026618666180531092503

Figure 3.

Figure 3

Schematic illustration of some of the most important costimulatory and coinhibitory interacting pairs [121, 122]. They belong to two main families, the immunoglobulin superfamily (CD28–CD80/86 and ICOS–ICOS-L), shown in the top half of the figure, and the TNF superfamily, shown in the bottom half of the figure, each containing more than 25 already identified members [126]. The repertoire of cosignaling pathways contains both immune-stimulatory (green) and -inhibitory (red) specific pathways as well as some ambiguous ones.