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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Matrix Biol. 2018 Jan 31;78-79:272–283. doi: 10.1016/j.matbio.2018.01.022

Fig. 3.

Fig. 3

Distinct roles for HA in adult hippocampal neurogenesis and in mature neurons. HA (red) in the SGZ is believed to typically exist as a high molecular weight (HMW) molecule that keeps NSCs (green) in a quiescent state through signaling by CD44 expressed by NSCs. When NSCs need to expand in number, HA is digested, possibly by hyaluronidases like CEMIP, either relieving NSCs from the quiescence signals generated by HMW HA or by inducing proliferation in response to HA digestion products (small red dots). These NSCs migrate into the granule cell layer and differentiate into new neurons (yellow cell) that assemble PNNs with HA (red color surrounding the new neuron) around themselves. HA within these PNNs is also likely to be dynamically regulated to influence neuronal activity.