Fig. 3.

Analysis of the binding enthalpy. The activation energy parameters were obtained from the temperature dependence of the association rate constant following the Eyring approximation: ln (k_on)/T) = −(∆H^‡ / RT) + (∆S^‡/R) + ln (k_B/h) where k_on is the association rate constant, ∆H^‡ is the activation enthalpy, R is the gas constant, T is the absolute temperature, ∆S^‡ is the activation entropy, k_B is the Boltzmann constant, and h is the Planck constant.