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. 2018 Jul 31;8:11470. doi: 10.1038/s41598-018-29929-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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NDV-LaSota and the combination of TMZ and NDV reduce GBM cell growth in vitro. (A) We infected the T98G, LN18, U251, U87 and C6 cell lines with different MOIs (0, 0.1, 1, or 10) of NDV-LaSota and analyzed cell viability at 36 hours using an MTT assay. The data are presented as the mean ± SD, (*P < 0.01, n = 3, MOI 0.1 vs control, MOI 1 vs MOI 0.1, MOI 10 vs MOI 0.1). (B) Growth inhibition rates after infection of the same strains with the same MOIs as in (A). Every MOI of NDV-LaSota had lower inhibitory effects on HUVECs and HEB cells than on any cancer cell line. TMZ (200 μM) had the same effects on cancer cell lines and normal cell lines (*P < 0.01, n = 3, HUVECs and HEBs vs cancer cell lines). (C) GBM cells were treated with medium, TMZ (200 μM), NDV-LaSota (MOI 1), or a combination of TMZ (200 μM) and NDV-LaSota (MOI 1) (*P < 0.01, n = 3, TMZ and NDV vs control; Δ* P < 0.01, n = 3, TMZ and NDV vs TMZ alone or NDV alone). All results were obtained 36 hours after infection with NDV.