. 2017 Dec 4;15(5):539–541. doi: 10.1038/cmi.2017.130

Table 1.

Recent studies on B-cell-induced CD4⁺Foxp3⁻ regulatory T cells

Generation	Phenotype	Application	Implication	Reference
Splenic B2 and peritoneal B1a cell/monoclonal antibodies/CD4⁺CD25⁻ T cell	Treg-of-B2 and Treg-of-B1a, CD4⁺CD25⁺Foxp3⁻	In vitro suppression assay	Treg-of-B cells were generated in a cell–cell contact-dependent manner and had cell–cell contact-dependent inhibition	¹
Splenic B cell/OVA peptide/DO11.10 CD4⁺CD25⁻ T cell	Treg-of-B, CD4⁺CD25⁺Foxp3⁻ ICOS⁺CTLA4⁺PD1⁺LAG3⁺	Allergic asthma	Treg-of-B cells may be involved in oral tolerance and had non-antigen-specific inhibition	²
Peyer’s patch B cell/OVA peptide/DO11.10 CD4⁺CD25⁻ T cell	Treg-of-B(P), CD4⁺CD25⁺Foxp3⁻	Allergic asthma	Treg-of-B(P) cells may be involved in oral tolerance	³
Peyer’s patch B cell/OVA peptide/DO11.10 CD4⁺CD25⁻ T cell	Treg-of-B(P), CD4⁺CD25⁺Foxp3⁻LAG3⁺	Allergic asthma	LAG3 and IL-10 play roles in the suppression of Treg-of-B(P) cells	⁴
Splenic B cell/monoclonal antibodies/CD4⁺CD25⁻ T cell	Treg-of-B, CD4⁺CD25⁺Foxp3⁻LAG3⁺	Rheumatoid arthritis	LAG3 and IL-10 play roles in the suppression of Treg-of-B cells	⁵
Splenic B cell/OVA peptide/DO11.10 CD4⁺CD25⁻ T cell/long culture period	Long-term Treg-of-B, CD4⁺CD25⁺Foxp3⁻cMaf⁺ICOS⁺CTLA4⁺LAG3⁺PD1⁺	In vitro suppression assay	CTLA4 and IL-10 play roles in the suppression of long-term Treg-of-B cells but not short-term Treg-of-B cells	⁶
Splenic B cell/monoclonal antibodies/CD4⁺CD25⁻ T cell	Treg-of-B, CD4⁺CD25⁺Foxp3⁻ICOS⁺PD1⁺LAG3⁺	Inflammatory bowel disease	IL-10 is not essential for the suppressive ability of Treg-of-B cells	⁷
Splenic B cell/OVA peptide/DO11.10 CD4⁺CD25⁻ T cell	T-of-B, CD4⁺CD25⁺ Foxp3⁻CD62L⁺	Graft versus host disease	B-T form an immunological synapse during induction	⁸
Splenic B cell/OVA peptide/DO11.10 CD4⁺CD25⁻ T cell	T-of-B, CD4⁺CD25⁺Foxp3⁻CD62L⁺	In vitro suppression assay	Additional CD28 signals decrease the suppressive ability of B-cell-induced T cells	⁹