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. 2018 Jul 31;8:11485. doi: 10.1038/s41598-018-29250-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differential protein expression in adipose tissue of mice lacking Csf2. (A) Significantly changing proteins (FDR < 0.05) were identified between the wildtype and Csf2^−/− mice, with 24 unique to low-fat diet conditions, 41 unique to high-fat diet conditions, and 24 unique to high-fat + cholesterol diet conditions, and thirty significantly changing proteins common to all diets. (B) Expression profiles for the thirty conserved significantly changing proteins between Csf2^+/+ and Csf2^−/− across all diet types. Heatmap analysis was performed with hierarchical clustering applied to the sample and proteins. (C) The top five annotated biological processes that are enriched in the significantly changing proteins.