Fig. 2.

Metabolic and microbial group variability between healthy controls and Crohn’s disease patients. Similarities were assessed based on a principle coordinate analysis (PCoA) of the mapped abundance with Bray Curtis dissimilarity a, simulated abundances with Bray Curtis dissimilarity b, and reaction content with jaccard distance c. Based on the simulation, relative abundances d and metabolite concentrations of fermentation products e were compared (p-value determined by Wilcoxon rank-sum test). Microbial metabolic activities were displayed as the total population flux f