Table 1.

VISTA regulates the responses of diverse immune cell types in cancer, autoimmune and inflammatory diseases

Immune cell types	Function of VISTA in cancer, autoimmune, and inflammatory diseases
CD4+ and CD8+ effector T cells	Suppress T cell proliferation, effector cytokine production (IFN-g, IL-2 etc), and cytotoxicity (Cancer, GVHD)Suppress the differentiation of Th17 CD4+ T cells (EAE)
Foxp3+ CD4+ Tregs	Promote the induction of tumor-specific adaptive CD4+ Foxp3+ Tregs (Cancer, GVHD)
TCRgd T cells	Inhibit the peripheral homeostasis and cytokine production of IL-17-producing CD27− TCRgd T subsets (Psoriasis)
Myeloid dendritic cells and macrophages	Inhibit the production of inflammatory cytokines and chemokines (Cancer, lupus, and psoriasis)