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. 2018 Jul 31;8:11493. doi: 10.1038/s41598-018-29752-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Vessels density measurements from optical coherence tomography angiography (OCTA) compared with indocyanine green angiography (ICGA) and slit lamp photography (SLP). The Bland-Altman plot between the differences of vessels density measurements from OCTA and ICGA (y-axis) in (a) (OCTA and SLP in b) against the average vessels density measurements of the 2 methods (x-axis) —showing good agreement of vessels density obtained from both imaging methods. The measurements of the density of corneal vessels within the region of interest were obtained from 22 sets of matched OCTA and ICGA images and 23 sets of matched OCTA and SLP images. The mean difference between OCTA and ICGA = 1.5 ± 2.6% (95% CI, 0.9526 to 2.0957%, P < 0.0001). Limits of agreement (±1.96 SD) = 4.1 and −1.0%. The mean difference between OCTA and SLP = 2.3 ± 3.3% (95% CI, 1.5135 to 2.8416%, P < 0.0001). Limits of agreement (±1.96 SD) = 5.6 and −0.9%. Solid line = mean of the difference. Short dashed line = reference zero. Long dashed line = upper and lower 95% limits of agreement (mean + 1.96 SD, mean −1.96 SD). SD = standard deviation of the mean difference.