Fig. 6.

Therapeutic efficacy of topical ferumoxytol/H₂O₂ against a biofilm-associated oral disease (tooth decay) in vivo. In this model, tooth-enamel progressively develop caries lesions (analogous to those observed in humans), proceeding from initial areas of demineralization to moderate lesions and on to extensive (severe) lesions characterized by enamel structure damage and cavitation. a Experimental design and treatment regimen. b Body weights of rat pups during the experimental period. c Caries onset and severity of both smooth and sulcal surfaces. Caries scores were recorded as stages and extent of carious lesion severity according to Larson’s modification of Keyes’ scoring system^26,27. The data presented as mean ± s.d. (n = 10), and one-way ANOVA with post hoc Tukey HSD test was used for a multiple comparison. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001; n.d. nondetectable; n.s. nonsignificant