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. 2018 Jul 31;8:11475. doi: 10.1038/s41598-018-29659-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hypoxia increases neutrophil-driven matrix destruction. (a) Confocal microscopy shows increased Type I collagenase activity in CoMTB-stimulated neutrophils in hypoxia compared to normoxia. (b) Neutrophils were stimulated with CoMCont or CoMTB and breakdown of DQ collagen analysed by quantitative fluorescent assay. (c) Pro-MMP-9 gelatinase activity is increased in hypoxia. MMP-9 activity by gelatin zymography with representative densitometric analysis. Zymogram representative of an experiment performed in triplicate from 2 independent experiments. Original gel is in Supplementary Figure 3. N, normoxia; H, hypoxia. ***p < 0.001, ****p < 0.0001 by 2-way ANOVA with Bonferonni post-test. Bars represent mean ± s.e.m of all data points from 3 donors each in triplicate normalized to hypoxia CoMTB.