Figure 3. KLF2 mediates CB chemoreflex sensitivity and resting RSNA in CHF rabbits.

A, representative records illustrating resting RSNA and ventilation and the response to poikilocapnic hypoxia ($F_{\mathrm{I}{\mathrm{O}}_2}$ 0.10) in CHF rabbits with and without CB KLF2 transfection and in sham rabbits with CB KLF2 siRNA or CB scrambled siRNA. B, summary data showing enhanced resting RSNA and enhanced minute ventilation and RSNA responses to hypoxia in CHF‐empty and KLF2 siRNA rabbits. CB KLF2 transfection had a salutary effect in CHF rabbits. n = 8 rabbits per group, except scrambled siRNA (n = 6). ^* P < 0.05 CHF‐empty vs. sham condition. ^# P < 0.05 CHF‐empty vs. CHF‐KLF2. Results are expressed as mean ± SEM.