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. 2017 Oct 11;596(15):3171–3185. doi: 10.1113/JP273805

Figure 4. CB KLF2 contributes to oscillatory breathing in CHF rabbits.

Figure 4

A, representative records of ventilation in CHF rabbits with KLF2 or empty virus transfection to the CB and in sham rabbits with CB KLF2 siRNA or CB scrambled siRNA transfection. Oscillatory breathing in CHF is virtually abolished by CB KLF2 transfection, whereas CB KLF2 siRNA transfection precipitates oscillatory breathing. B, mean data showing cross‐sectional (left) and longitudinal (right) group comparisons of oscillatory breathing in CHF rabbits with CB KLF2 or CB empty transfection and sham rabbits transfected with KLF2 siRNA or scrambled siRNA as quantified by the apnoea hypopnea index (AHI) and respiratory rate variability index (RRVI). n = 8 rabbits per group, except scrambled siRNA (n = 6). * P < 0.05 vs. pre‐pace or sham. # P < 0.05 vs. CHF‐empty. ‡ P < 0.05 vs. scrambled siRNA. † P < 0.05 vs. CHF. Results are illustrated as a scatter plot with mean indicated by the horizontal black bar. For longitudinal data, individual animals were assigned a specific colour, which may be observed at each respective timepoint.