Table 2.
Heart rate variability analysis
| Sham | Pre | Post |
|---|---|---|
| SDNN (ms) | 14 ± 1 | 13 ± 1 |
| Total power (ms2) | 200 ± 31 | 187 ± 37 |
| LF (nu) | 27 ± 5 | 25 ± 3 |
| HF (nu) | 47 ± 3 | 40 ± 2 |
| LF/HF ratio | 0.6 ± 0.1 | 0.6 ± 0.1 |
| CHF‐empty | Pre‐pace | CHF | CHF post‐virus |
|---|---|---|---|
| SDNN (ms) | 14 ± 1 | 9 ± 1* | 8 ± 1*# |
| Total power (ms2) | 192 ± 30 | 66 ± 14* | 70 ± 22*# |
| LF (nu) | 22 ± 4 | 25 ± 3 | 30 ± 5 |
| HF (nu) | 36 ± 5 | 25 ± 3 | 26 ± 4# |
| LF/HF ratio | 0.6 ± 0.1 | 1.0 ± 0.1* | 1.2 ± 0.2*# |
| CHF‐KLF2 | Pre‐pace | CHF | CHF post‐virus |
|---|---|---|---|
| SDNN (ms) | 15 ± 1 | 10 ± 1* | 15 ± 2† |
| Total power (ms2) | 196 ± 47 | 91 ± 15* | 210 ± 49† |
| LF (nu) | 19 ± 3 | 23 ± 4 | 22 ± 3 |
| HF (nu) | 39 ± 3 | 27 ± 2* | 43 ± 4† |
| LF/HF ratio | 0.5 ± 0.1 | 0.8 ± 0.1* | 0.5 ± 0.1† |
| Scrambled siRNA | Pre‐virus | Post‐virus |
|---|---|---|
| SDNN (ms) | 14 ± 3 | 15 ± 4 |
| Total power (ms2) | 185 ± 78 | 233 ± 125 |
| LF (nu) | 31 ± 3 | 25 ± 3 |
| HF (nu) | 49 ± 3 | 39 ± 3 |
| LF/HF ratio | 0.7 ± 0.1 | 0.7 ± 0.1 |
| KLF2 siRNA | Pre‐virus | Post‐virus |
|---|---|---|
| SDNN (ms) | 14 ± 2 | 12 ± 1 |
| Total power (ms2) | 194 ± 38 | 159 ± 25 |
| LF (nu) | 19 ± 3 | 29 ± 3* |
| HF (nu) | 46 ± 3 | 35 ± 3* |
| LF/HF ratio | 0.4 ± 0.1 | 0.9 ± 0.2* |
SDNN = standard deviation of the normalized RR interval; LF = low‐frequency power; HF = high‐frequency power; nu = normalized units. * P < 0.05 compared to respective baseline condition (pre‐pace or pre‐virus), # P < 0.05 compared to sham, † P < 0.05 compared to CHF. n = 8 rabbits per group, except scrambled siRNA (n = 6).