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. 2018 Jul 25;9:1693. doi: 10.3389/fimmu.2018.01693

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Copyright © 2018 Moreno-Torres, González-García, Marconi, García-Grande, Rodríguez-Esparragoza, Elvira, Ramil, Campos-Ruíz, García-Hernández, Al-Shahrour, Fustero-Torre, Sánchez-Sanz, García-Merino and Sánchez López.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nonparametric multidimensional scaling of selected lymphocytes subpopulations that discriminates responders and non-responder patients. A 2D representation by nonparametric multidimensional scaling (Seuclidean method) of the percentages of four selected lymphocyte subpopulations measured before treatment [natural killer (NK) bright, NK dim, plasmablasts, and IL-2-producing cells]. Individual patients and distance from the average of each condition are shown. Patients with a good response to fingolimod at 1 year (NEDA-3 and NEDA-4) were located in a well-differentiated region of space when the subpopulations are measured before treatment. At 2 years, this differentiation was less evident.