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. 2018 Jul 25;9:1713. doi: 10.3389/fimmu.2018.01713

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Copyright © 2018 Huang, He, Liang, Hu, Jiang, Yang, Mei, Zhu, Yu, Kijlstra, Yang and Hou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TCDD treatment shifted the polarization of macrophages/microglia from M1 to M2 in experimental autoimmune uveitis mice. (A) Left, representative immunofluorescent images of ionized calcium-binding adaptor molecule 1 (Iba1) and DAPI in retinas of naive, vehicle, and TCDD-treated mice. Scale bar, 10 µm. Right, quantification of relative integrated optic density (IOD) of Iba1 (n = 4/group; mean ± SD;^*** p < 0.001; one-way ANOVA). (B) Left, representative western blotting images of inducible nitric oxide synthase (iNOS), arginase-1 (Arg-1), CD16, and CD206 in retinas of naive, vehicle, and TCDD-treated mice. Right, quantifications of relative fold change of iNOS, Arg-1, CD16, and CD206 expressions (n = 4/group; mean ± SD;^*** p < 0.001; one-way ANOVA).