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. 2018 Jan 4;596(15):3087–3100. doi: 10.1113/JP274833

Figure 2. ROS scavenger prevents LT‐IH‐evoked increase in ROS and AOE gene repression in the nTS and RVLM.

Figure 2

Micro‐punches of nTS, RVLM and a control region in the brainstem were obtained from rats exposed to room air, vehicle‐treated rats exposed to 30 days of IH (LT‐IH + vehicle), and MnTmPyP‐treated rats exposed to 30 days of IH (LT‐IH + MnTmPyP). A, anatomical localization of nTS (red), RVLM (red), and a control brainstem region (Control, blue) based on adult rat brain atlas (Paxinos & Watson, 2006). B and C, effect of LT‐IH on malondialdehyde (MDA) levels (index of ROS) (B), AOE gene expression (Sod1, Sod2, superoxide dismutase 1 and 2; Cat, catalase; Txnrd2, thioredoxin reductase; Prdx4, peroxiredoxin 4; Gpx2, glutathione peroxidase 2) in the control brainstem region (control area), nTS and RVLM (C). D and E, effects of MnTmPyP on LT‐IH‐induced AOE gene repression in nTS (D) and RVLM (E). Data presented as means ± SEM, n = 9 rats per group; ** P < 0.01; * P < 0.05; ns, not significant, P > 0.05.