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. 2018 Jan 4;596(15):3087–3100. doi: 10.1113/JP274833

Figure 9. Effect of GSK 690693 on DNA methylation, AOE mRNAs, plasma noradrenaline (NA) and mean blood pressures (MBP) in rats exposed to LT‐IH.

Figure 9

Rats exposed to room air or exposed to LT‐IH and were treated with either vehicle (LT‐IH + vehicle) or GSK 690693 (LT‐IH + GSK690693), a pan‐Akt inhibitor during the first 10 days of IH exposure. A, DNA methylation of AOE genes expressed as percentage of methylated cytosines (methylated C). B, mRNA abundances of AOE genes normalized to 18S rRNA and expressed as relative change from room air controls. C, plasma NA levels. D, mean blood pressure (MBP). Data are presented as means ± SEM from 9 independent experiments. * P < 0.05; ns, not significant, P > 0.05 compared to room air exposed control rats.