. 2018 Apr 24;596(15):3371–3389. doi: 10.1113/JP275913

Table 1.

Protocol 1 systemic haemodynamic and ventilatory responses

	Rest 1	Normoxic exercise	Rest 2	Steady‐state hypoxia	Hypoxic exercise
Control
MAP (mmHg)	90 ± 2	95 ± 1†	91 ± 2	94 ± 2	97 ± 2†
HR (beats min⁻¹)	59 ± 4	69 ± 6†	59 ± 3	75 ± 4†	79 ± 4†‡
FVC (mL min⁻¹ 100 mmHg⁻¹)	91.4 ± 14.9	357.3 ± 40.1†	91.2 ± 17.1	117.0 ± 24.8†	415.9 ± 44.8†‡
$S_{p O_{2}}$ (%)	99 ± 0	98 ± 1	99 ± 0	82 ± 2†‡	82 ± 1†‡
Minute vent. (L min⁻¹; BTPS)	8.4 ± 0.4	10.5 ± 0.6	9.1 ± 0.4	17.0 ± 1.4†‡	23.1 ± 2.3†‡#
End‐tidal CO₂ (mmHg)	40.2 ± 0.7	38.7 ± 0.9	39.1 ± 1.4	38.6 ± 0.9	39.5 ± 1.0
NO, PG, Na⁺/K⁺‐ATPase, K_IR channel block
MAP (mmHg)	98 ± 2*	105 ± 2*†	97 ± 3*	103 ± 3*†	106 ± 2*†
HR (beats min⁻¹)	57 ± 3	63 ± 4*	57 ± 3	75 ± 3†‡	79 ± 4†‡
FVC (mL min⁻¹ 100 mmHg⁻¹)	41.0 ± 6.1*	244.4 ± 31.1*†	41.5 ± 7.4*	36.9 ± 5.0*	270.3 ± 31.2*†‡
$S_{p O_{2}}$ (%)	99 ± 0	98 ± 1	99 ± 0	84 ± 1*†‡	82 ± 1†‡
Minute vent. (L min⁻¹; BTPS)	9.5 ± 0.7	11.4 ± 0.6	8.8 ± 0.7	22.1 ± 1.6*†‡	28.8 ± 2.7*†‡#
End‐tidal CO₂ (mmHg)	37.3 ± 1.3*	36.5 ± 1.1*	38.1 ± 0.8	38.0 ± 0.9	38.5 ± 1.0‡

BTPS, body temperature and pressure, saturated.

^* P < 0.05 vs. control; ^† P < 0.05 vs. rest (within trial); ^‡ P < 0.05 vs. normoxic exercise; ^# P < 0.05 vs. hypoxia; all comparisons within protocol; $S_{p O_{2}}$ , oxygen saturation via pulse oximetry.