FIGURE 7.
Neurite length is decreased in response to Aβ1-42 in wild type (WT) neurons but not in CLU knockout (CLU-/-) neurons. Neurons from three independent differentiations of both WT and CLU-/- lines were treated with 0–3 μM Aβ1-42 oligomers for 48 h neuronal processes and neurite length was measured by automated image analysis. (A) Neurite length in WT neurons treated with 0–3 μM Aβ1-42 and representative images at 0 and 3 μM. (B) Neurite length in CLU-/- neurons treated with 0–3 μM Aβ1-42 and representative images at 0 and 3 μM. (∗p < 0.05, ∗∗p < 0.005). Scale bars represent 50 μm.