Table 1.

Mechanisms of action for sirtuin family members.

Sirtuin	Catalytic Activities
SIRT1	Deacetylase (Michishita et al., 2005),
	Decrotonylase (Bao et al., 2014)
SIRT2	Deacetylase (Perrod et al., 2001; North et al., 2003),
	Decrotonylase (Bao et al., 2014)
SIRT3	Deacetylase (Schwer et al., 2002),
	Decrotonylase (Bao et al., 2014)
SIRT4	ADP-ribosyltransferase (Ahuja et al., 2007),
	Lipoamidase (Mathias et al., 2014)
SIRT5	Deacetylase (Schlicker et al., 2008)
	Demalonylase (Du et al., 2011; Peng et al., 2011),
	Desuccinylase (Du et al., 2011; Peng et al., 2011)
	Glutarylate (Tan et al., 2014)
SIRT6	ADP-ribosyltransferase (Liszt et al., 2005);
	Deacetylase (Michishita et al., 2008),
	Acylate (Jiang et al., 2013)
SIRT7	Deacetylase (Vakhrusheva et al., 2006, 2008)