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Inhibition of TNF-induced death in L929 cells. Increasing concentrations of A11 (A) or A25 (B) at 0.6–80 μM, and adalimumab (C) at 0.005–10 nM were used to pre-incubate recombinant human TNF (10 ng/ml) before addition to L929 cells for 18 h. Mean values (n = 3) relative to controls (TNF pre-incubated with DMSO or PBS in the adalimumab case) are shown. Data shown are representative of at least three experiments.
