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. 2018 Jun 14;12(8):1324–1341. doi: 10.1002/1878-0261.12328

Figure 5.

Figure 5

Lipopolysaccharide‐induced TNF‐α factor is aberrantly expressed in human prostate tumors. (A) LITAF shows the opposite trend as miR‐106a expression, with significantly lower expression in prostate cancer compared to normal tissue (P = 0.02; n = 487 tumor and n = 52 normal matched; two‐sided Wilcoxon test). (B) LITAF shows lower expression in Gleason score (GS) >7 tumors compared to GS ≤7 tumors (P = 4.07 ×  10‐5; n = 287 for GS ≤7 and n = 200 for GS >7; two‐sided Wilcoxon test). (C) Low LITAF expression is associated with lower BCR‐free survival at 5 years (391 tumors; P = 8.41 ×  10−3). (D) The relationship between BCR‐free survival and four combinations of miR‐106a and LITAF expression is shown. High miR‐106a and low LITAF expression show the lowest BCR‐free survival (391 tumors; P = 0.004; log‐rank test).