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Dosing optimization study summary
| Animal# | Group# | 1st course | 2nd course | |||||
|---|---|---|---|---|---|---|---|---|
| Dose (μg·kg−1) | Days | Depletion | Antibody Formation a | Dose (μg·kg−1) | Days | Depletion | ||
| M10916 | 1 | 50 | 4 | ++++ | Yes | |||
| M11216 | 1 | 50 | 4 | ++++ | Yes | 25 | 8 | – |
| 25 | 4 | |||||||
| M11016 | 2 | 25 | 8 | ++++ | Yes | 25 | 8 | – |
| M11116 | 2 | 25 | 8 | ++++ | Yes | 25 | 3 | – |
++++ more than 80% of CCR4+Foxp3+ Treg depletion; – almost no depletion of CCR4+Foxp3+ Treg.
aAntibody formation against the CCR4 immunotoxin at around 2 weeks.
