Table 1.
Papers reporting cases of intracranial HPC that developed bone metastases.
| Author | N pts | Metastases (%) | Site of metastases | Time to met (median) | Treatment of bone | Outcome metastases |
|---|---|---|---|---|---|---|
| Goellner, 1978 | 26 | 23 | Retroperitoneum, liver, lung, bones Bones | 8.6 yrs | Unavailable | Unavailable |
| Anderson, 1980 | 1 | 100 | Bones | 5 yrs | Surgery + RT (femur) RT CHT | Slowly progressive disease at 3 yrs |
| Jaaskelainen, 1985 | 21 | 14 | Bones, liver, pleura, lung, subcutis | 6,4 yrs | Unavailable | Slowly progressive disease at 6,5 yrs |
| Staples, 1990 | 15 | 53 | Bones, lung, subcutaneous tissue, massive intraddominal disease | 3 yrs | RT (26-30 Gy, 10-13 fr) | NED after 11 yrs |
| Sakata, 1998 | 1 | 100 | Bones | 20 yrs after the first treatment | RT (60 Gy in 24 fr over 5 weeks, 39 Gy in 13 fr over 3 weeks, 20 Gy in 4 fr over 2 weeks) + CHT | Partial response and no regrowth; good palliation |
| Dufour, 2001 | 21 | 19 | Bones, lung | 12 yrs | Unavailable | Slowly progressive disease at 4 yrs |
| Someya, 2001 | 4 | 50 | Bones liver, lung, brain | 7.5 yrs | RT bone 1: 25 Gy in 5 fr, 50 Gy in 16 fr S→ RT: 37.5 Gy in 15 fr RT bone 2: 25 Gy in 5 fr RT bone 3: 35 Gy in 8 fr | Death after 9 years |
| Suzuki, 2002 | 1 | 100 | Pancreas, bones | 22 yrs | RT | SD at 2 yrs |
| Ecker, 2003 | 38 | 29 | Spine, chest wall, liver, pelvis, lungs, orbit, femur, deltoid, breast, humerus | Unavailable | Radiosurgical tratment and salvage chemotherapy treatment | 5 yrs survival rate 93% |
| Kim, 2003 | 31 | 12.9 | Liver, lung bones | 8.9 yrs | Unavailable | Unavailable |
| Souyer, 2004 | 29 | 55 | Lung, bone, liver, spinal | 97 months | Gross total resection or subtotal resection + or - RT | The 5, 10 and 15-year overall survival rates 85%, 68% and 22% |
| Pistolesi, 2004 | 1 | 100 | Bones, Adrenal glands | 12 yrs | Surgery (femur) RT (30 Gy in 10 fractions) (vertebra) | NR |
| Chang, 2004 | 1 | 100 | Bones, liver | 5 yrs | RT 43.2 Gy | PD at 1 yr |
| Hoshi, 2005 | 15 | 100 | Bones | >10 yrs | RT, S | Unavailable |
| Fountas, 2006 | 11 | 36.4 | Bones, liver, lung | 4.9 yrs | Unavailable | All dead |
| Purandare, 2010 | 1 | 100 | Bones | 8 yrs | RT (dse not specified) | SD at few months |
| Bassiouni, 2007 | 12 | 17 | Unavailable | Unavailable | Unavailable | Unavailable |
| Ywamuro, 2008 | 1 | 100 | Bones, liver | 9 yrs | S | SD at 5 years |
| Ambrosini- Spaltro, 2010 | 1 | 100 | Hip | 13 yrs | Unavailable | Unavailable |
| Schiariti, 2011 | 39 | 26 | Lung, bones, liver, muscle | 75 months after their initial surgery | Surgical excision and EBRT when radical excision no possible and/or chemotherapy | Overall survival rates at 5, 0, 15, and 20 yrs 93%, 1 67%, 45% and 23% |
| Rutkoski, 2012 | 35 | 20 | Liver, skin, bone lung | Unavailable | Unavailable | 4/7 died |
| Siegel, 2012 | 1 | 100 | Bones | 13 yrs | S (wide resection) | NED at 7 yrs |
| Kumar, 2012 | 15 | 7 | Bones | 5 yrs | RT (dose not specified) | Unavailable |
| Ghia, 2013 | 63 | 33 | Unavailable | 10 yrs | RT | Unavailable |
| Stessin, 2013 | 76 | Unavailable | Unavailable | Unavailable | Total resection or Subtotalresection + RT | Unavailable |
| Satayasoontorn, 2014 | 4 | 100 | Bones | 7 yrs | Unavailable | Unavailable |
| Manatakis, 2015 | 1 | 100 | Bone, liver | 12 yrs | SRS | Unavailable |
| Nakada, 2015 | 2 | 100 | Bones | 8 yrs | Unavailable | Unavailable |
| Yamazaky, 2016 months | 1 | 100 | Rib | 2 yrs | S | PD (multiple bone met) after 6 |
| Wei, 2015 | 1 | 100 | Bones, kidneys | 4 yrs | C (bevacizumab + temozolomide) + RT (40 Gy in 10 fr) | Stable disease |