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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Autoimmun Rev. 2017 Apr 17;16(6):612–619. doi: 10.1016/j.autrev.2017.04.008

Figure 2. RNA-sequencing transcriptome database of glia, neurons, and vascular cells of the cerebral cortex:

Figure 2.

NMDAR subunits (Grin2a (Nr2a) & Grin2b (Nr2b)) or the C5a complement receptor (C5ar1) have been implicated in NPSLE related endothelial activation/apoptosis, based on in vitro studies. However, low to negligible transcript levels in BBB endothelial cells in vivo have been seen. As expected, these gene transcripts are most abundant in neurons and microglia, respectively (FPKM of 0.1 represents noise threshold of the data and FPKM>10 is readily detectable by qPCR). This observation is true for both human and mouse BBB endothelial cells. Adapted from [82].