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. 2018 Jul 25;9:1651. doi: 10.3389/fmicb.2018.01651

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Copyright © 2018 Sato, Yagishita, Tamaki, Inoue, Hasegawa, Nagasaka, Suzuki, Araya, Coler-Reilly, Hasegawa, Tsuboi, Takata and Yamano.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Kaplan–Meier analysis. Kaplan–Meier analysis to evaluate time from Osame motor disability score (OMDS) grade 2 to deteriorating to OMDS grade 6 for the following patient group defined by the difference of the clinical course from onset: rapid progressors (red line), slow progressors (blue line), and very slow progressors (green line). The horizontal axis represents the elapsed years from OMDS grade 2. The vertical axis represents percentage of patients who have not reached OMDS grade 6. Numbers shown below the graph indicate number at risk. Differences in the degree of progress among the three groups were tested by log-rank test. Significance was defined as p < 0.05.