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. 2018 Jun 13;9(8):939–949. doi: 10.1111/1759-7714.12767

Figure 5.

Figure 5

OIP5‐AS1 promoted A549 and H520 cell proliferation by competitively binding miR‐378a‐3p. Binding‐site‐mutated OIP5‐AS1 did not exert the proliferation promoting function. (a) Methyl thiazolyl tetrazolium assay was conducted in A549 and H520 cells after transfection with OIP5‐AS1‐WT or OIP5‐AS1‐Mut vectors and miR‐378a‐3p mimics. (b) Ki67, CDK4, and CDK6 protein expression in lung cancer cells after transfection with OIP5‐AS1‐WT or OIP5‐AS1‐Mut vectors and microRNA mimics. Non‐treated A549 and H520 cells were used as the control.