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. 2017 Dec 5;52(4):351–364. doi: 10.1177/0023677217739934

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Nociceptive testing results. (a) Mean (combined paws) electronic von Frey (eVF) thresholds (grams ± 1SEM) in BALB/c mice in the single- and multiple-dose 4T1 cohorts versus non-cancer controls; showing the significant decline over time in all mice, but more so in cancer groups. (b) Left paw thermal withdrawal thresholds (mean ± SEM) in the same groups as (a); showing increased thermal sensitivity as tumours grew. (c) eVF threholds (both paws) in the B16 groups where thresholds generally declined during tumour development. (d) Mean thermal (both paws) withdrawal thresholds (±SEM) in the B16 groups showing thermal response thresholds were not significantly altered as cancer developed. Significant (Sig.) ‘factors’ from repeated measures ANOVA and p-values are indicated.